MAJOR ROLE OF S-GLYCOPROTEIN IN PROVIDING IMMUNOGENICITY AND PROTECTIVE IMMUNITY IN MRNA LIPID NANOPARTICLE VACCINES BASED ON SARS-COV-2 STRUCTURAL PROTEINS

SARS-CoV-2 variants have evolved over time in recent years, demonstrating immune evasion of vaccine-induced neutralizing antibodies directed against the original S protein.Updated S-targeted vaccines provide a high level of protection against circulating variants of SARS-CoV-2, but this protection declines over time due to ongoing virus evolution.T

Metastasizing cancer cells encounter a multitude of stresses throughout the metastatic cascade.Oxidative stress is known to be a major barrier for metastatic colonization, such that metastasizing cancer cells must rewire their metabolic pathways to increase their antioxidant capacity.NADPH is essential for regeneration of cellular antioxidants and

This study presents the optimal design of a magnetic excitation model for developing a nondestructive sensor for coal mine hoist wire ropes.The model was established using axial-symmetry finite-element analysis and calculations.The influence of the excitation device parameters on the local magnetization effect of the wire rope was investigated in d

High-precision rainfall field reconstruction and nowcasting play an important role in many aspects of social life.In recent years, the rain-induced signal attenuation of oblique Personal Care earth-space links (OELs) has been presented to monitor regional rainfall.In this paper, we set up the first OEL in Nanjing, China, for the estimation of rain

Abstract The widespread bacterial genus Sulfurimonas is metabolically versatile and occupies a key ecological niche in different habitats, but its interaction with bacteriophages remains unexplored.Here we systematically investigated the genetic diversity, taxonomy and interaction patterns of Sulfurimonas-associated phages based on sequenced microb